SAFETY AND PHARMACOKINETICS OF VITAMIN-A THERAPY FOR INFANTS WITH RESPIRATORY SYNCYTIAL VIRUS-INFECTIONS

Authors
NEUZIL KM GRUBER WC CHYTIL F STAHLMAN MT GRAM BS
Citation
Km. Neuzil et al., SAFETY AND PHARMACOKINETICS OF VITAMIN-A THERAPY FOR INFANTS WITH RESPIRATORY SYNCYTIAL VIRUS-INFECTIONS, Antimicrobial agents and chemotherapy, 39(5), 1995, pp. 1191-1193
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
39
Issue
5
Year of publication
1995
Pages
1191 - 1193
Database
ISI
SICI code
0066-4804(1995)39:5<1191:SAPOVT>2.0.ZU;2-C
Abstract
Infants with respiratory syncytial virus infection have low serum vita min A levels. We treated 21 respiratory syncytial virus-infected child ren with 12,500 to 25,000 IU of oral vitamin A. Vitamin A levels were normalized at 6 h, and none of the children experienced vitamin A toxi city or exacerbation of respiratory illness. Vitamin A treatment of pr eviously healthy respiratory syncytial virus-infected infants at these doses is safe and well tolerated.