NOVEL MUTATION IN THE UL97 GENE OF A CLINICAL CYTOMEGALOVIRUS STRAIN CONFERRING RESISTANCE TO GANCICLOVIR

Authors
HANSON MN PREHEIM LC CHOU SW TALARICO CL BIRON KK ERICE A
Citation
Mn. Hanson et al., NOVEL MUTATION IN THE UL97 GENE OF A CLINICAL CYTOMEGALOVIRUS STRAIN CONFERRING RESISTANCE TO GANCICLOVIR, Antimicrobial agents and chemotherapy, 39(5), 1995, pp. 1204-1205
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
39
Issue
5
Year of publication
1995
Pages
1204 - 1205
Database
ISI
SICI code
0066-4804(1995)39:5<1204:NMITUG>2.0.ZU;2-#
Abstract
Characterization of a ganciclovir-resistant cytomegalovirus strain fro m a patient with AIDS showed a histidine-to-glutamine change at residu e 520 of UL97 (Q520 mutation). In anabolism studies, Q520 was associat ed,vith impaired phosphorylation of ganciclovir. Transfer of Q520 to a recombinant virus resulted in a ganciclovir-resistant phenotype.