K. Katsuda et al., ANTIGENIC AND GENETIC-CHARACTERISTICS OF H1N1 HUMAN INFLUENZA-VIRUS ISOLATED FROM PIGS IN JAPAN, Journal of General Virology, 76, 1995, pp. 1247-1249
Two strains of influenza A virus were isolated from pigs in northern J
apan in 1992. Serological tests showed that the haemagglutinin (HA) an
d neuraminidase (NA) antigens were more closely related to those of re
cent human H1N1 viruses than to those of swine H1N1 viruses. The HA an
d NA genes of isolate A/sw/Obihiro/5/92 were shown to be closely relat
ed to those of current human H1N1 viruses. Evolutionary trees construc
ted from nucleotide sequences showed that the HA and NA genes of A/sw/
Obihiro/5/92 were apparently on a branch cluster containing human stra
ins isolated between 1990 and 1992.