MORPHOLOGICAL EXAMINATION OF RABBIT NASAL-MUCOSA AFTER EXPOSURE TO ACETYLSALICYLIC-ACID, GLYCOFUROL-75 AND EPHEDRINE

The potential local toxicity of glycofurol 75 and 30% acetylsalicylic acid in glycofurol 75 for nasal application has been evaluated in rabb its. The commercially available 1% ephedrine nose drops were used as a clinical relevant standard. Acetylsalicylic acid may be of potential use in acute myocardial infarction, where the cost/benefit of an insta nt nasal application may be favourable. 4 h after application of nasal solutions, 50 mu l into each nostril, the mucosa of septae and concha e were examined with respect to gross and histopathological changes, A ll solutions tested resulted in lesions that exceeded normal variation s. Most of the inflammatory reactions in the acetylsalicylic acid grou p seemed reversible within 7 days, at which time, however, osteoblast and osteoclast activity and formation of osteoid were pronounced.