K. Zuurman et al., EFFECT OF BINDER ON THE RELATIONSHIP BETWEEN BULK-DENSITY AND COMPACTIBILITY OF LACTOSE GRANULATIONS, International journal of pharmaceutics, 119(1), 1995, pp. 65-69
The effect of a binder on the relationship between the bulk density an
d compactibility of lactose granulations was studied by comparing bind
erless granules with granules containing hydroxypropylcellulose. Granu
lations were prepared from different grades of alpha-lactose monohydra
te and anhydrous beta-lactose, respectively, using two different wet g
ranulation techniques. The results show that the effect of the binder
on tablet strength is independent of the type of lactose used, but is
significantly influenced by the consolidation and compaction behaviour
of the lactose particles. The effectivity of the binder increases wit
h a decrease of the bulk density of the granule powder bed. Tablets wi
th a high crushing strength can be prepared from porous granules, cont
aining a binder.