UTILIZATION OF DIFFERENTIAL SCANNING CALORIMETRY AS A SCREENING TECHNIQUE TO DETERMINE THE COMPATIBILITY OF KETOPROFEN WITH EXCIPIENTS

Differential scanning calorimetry (DSC) was used as a screening techni que for assessing the compatibility of ketoprofen with some excipients currently employed in tablet or capsule formulations. The effect of s ample treatment (simple blending, cogrinding, compression, kneading) w as also evaluated. On the basis of DSC results, ketoprofen was found t o be compatible with hydroxyethylcellulose? hydroxypropylcellulose. mi crocrystalline cellulose, corn starch, arabic gum, colloidal silica, v eegum, lactose, glucose, sorbitol and mannitol. Some drug-excipient in teraction was observed with palmitic acid, stearic acid and stearyl al cohol and eutectic formation was found with magnesium stearate. Strong solid-phase interaction with polyethylene glycol 6000, polyvinylpolyp yrrolidone and even more with polyvinylpyrrolidone K30 was found.