FINE MAPPING OF 5 HUMAN SKELETAL-MUSCLE GENES - ALPHA-TROPOMYOSIN, BETA-TROPOMYOSIN, TROPONIN-I SLOW-TWITCH, TROPONIN-I FAST-TWITCH, AND TROPONIN-C FAST

Authors
TISO N RAMPOLDI L PALLAVICINI A ZIMBELLO R PANDOLFO D VALLE G LANFRANCHI G DANIELI GA
Citation
N. Tiso et al., FINE MAPPING OF 5 HUMAN SKELETAL-MUSCLE GENES - ALPHA-TROPOMYOSIN, BETA-TROPOMYOSIN, TROPONIN-I SLOW-TWITCH, TROPONIN-I FAST-TWITCH, AND TROPONIN-C FAST, Biochemical and biophysical research communications, 230(2), 1997, pp. 347-350
Citations number
22
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
230
Issue
2
Year of publication
1997
Pages
347 - 350
Database
ISI
SICI code
0006-291X(1997)230:2<347:FMO5HS>2.0.ZU;2-0
Abstract
In this paper the chromosomal localization of the human skeletal muscl e genes Troponin-I slow-twitch (TNNI1), Troponin-I fast-twitch (TNNI2) , and Troponin-C fast (TNNC2) and the refinement of the position for a lpha-Tropomyosin (TPM1) and beta-Tropomyosin (TPM2) are reported. By r adiation hybrid mapping, TPM1 was assigned to chromosome 15q22.1, TPM2 to chromosome 9p13.2-p13.1, TNNI1 to chromosome 1q31.3, TNNI2 to chro mosome 11p15.5, and TNNC2 to chromosome 20q12-q13.11. The genomic dist ribution of these genes is discussed, with particular emphasis on the cluster organization of the Troponin genes. (C) 1997 Academic Press