TRANSMIGRATION OF FLUID RAPIDLY INFUSED INTO DOGS WITH RENAL BLOOD-VESSELS LIGATION AND INCREASED PULMONARY CAPILLARY-PERMEABILITY

To study the transmigration of fluid rapidly infused intravenously, la ctated-Ringer's solution was infused at the rate of 90 ml/kg/hr for 30 min into generally anesthetized dogs. Four groups were made; group C with no fluid infusion as the control, group F with rapid fluid infusi on only, group LF with renal blood Vessels ligation and rapid fluid in fusion, and group OF with increased pulmonary capillary permeability e xperimentally induced by oleic acid and rapid fluid infusion. The extr avascular lung water volume (ELWV) was measured by the thermal-sodium double indicator dilution method, and the amounts of ascites and urine , and other clinical parameters were monitored before and after fluid infusion. The results show that in the dogs without increased pulmonar y capillary permeability excessive fluid is mainly excreted as urine ( group F) or transudates into the abdominal cavity (group LF). But in t he dogs with increased pulmonary capillary permeability (group OF) exc essive fluid easily and rapidly transudated into the pulmonary interst itium, resulting in pulmonary edema.