EFFECT OF TCV-309, A NOVEL PLATELET-ACTIVATING-FACTOR ANTAGONIST, ON HEMODYNAMICS IN DOGS WITH ENDOTOXIN-INDUCED SHOCK

The therapeutic effects of TCV-309, a never platelet activating factor antagonist, on hemodynamics in endotoxin-induced shock were evaluated . Ten Beagle dogs were used under general anesthesia and artificial ve ntilation. After intravenous injection of endotoxin (3 mg/kg), TCV-309 (1 mg/kg) was administered intravenously to the dogs. The results sho wed that the depression of mean aortic pressure, cardiac output, left ventricular stroke work index and urine volume which occurred in endot oxin shock was significantly improved by administration of TCV-309. Th ese results suggested that TCV-309 was a useful therapeutic for the ci rculatory disturbance in endotoxin shock.