POSSIBLE INTEGRATION OF THE ELECTRICAL-ACTIVITY OF THE DUODENUM AND PANCREAS SECRETION THROUGH ENTEROSTATIN

Pancreatic juice inter-digestive secretion was found to fluctuate rhyt hmically in pigs. Likewise, pancreatic juice secretion from calves was shown to oscillate and the peak secretion occurred during the irregul ar spiking activity (ISA) phase of the myoelectrical migrating complex (MMC). Re-introduction of the pancreatic juice into the duodenum was found to prolong the MMC of the intestine and decrease pancreatic juic e secretion. Enterostatin, a peptide released from pancreatic procolip ase in the intestine, was in the present work found to prolong MMC of the intestine by lengthening the no spiking activity (NSA) phase, when administered intraduodenally. Previously enterostatin was shown to in hibit pancreatic secretion. Therefore, we suggest that the factor in t he pancreatic juice regulating intestinal motility could be enterostat in.