NEUROTENSIN SECRETION AFTER PANCREATICODUODENECTOMY IN PATIENTS WITH PANCREATIC HEAD CANCER

Authors
SAKAMOTO T MIYATA M IZUKURA M TANAKA Y MIZUTANI S IWASE K TOMINAGA H MOMIYAMA T YOSHIDOME K MATSUDA H
Citation
T. Sakamoto et al., NEUROTENSIN SECRETION AFTER PANCREATICODUODENECTOMY IN PATIENTS WITH PANCREATIC HEAD CANCER, Biomedical research, 15, 1994, pp. 411-414
Citations number
10
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Biomedical research → ACNP
ISSN journal
03886107
Volume
15
Year of publication
1994
Supplement
2
Pages
411 - 414
Database
ISI
SICI code
0388-6107(1994)15:<411:NSAPIP>2.0.ZU;2-I
Abstract
To the purpose of elucidating the mechanism of Neurotensin (NT) secret ion after pancreatoduodenectomy (PD), we investigated NT secretion ind uced by fat ingestion in 8 patients with pancreatic head cancer before and after PD, and 7 patients with gastric cancer before and after dis tal gastrectomy. Both basal and postcibal (0-180 minutes) plasma level s of NT after PD were significantly higher than before PD. Plasma leve ls of NT after DG were significantly higher than before DG from 10 to 60 minutes after fat ingestion. There were no differences in plasma le vels of NT between patients after PD and after DG. The postoperative h ypersecretion of NT during the first 90 minutes observed in both patie nts after PD and after DG. However, the hypersecretion of NT during th e second 90 minutes observed only in PD patients. This results indicat e that resection of the distal stomach play one of causative roles in an augmentation of NT secretion by fat ingestion after PD.