EFFECT OF CHRONIC PANCREATIC-JUICE DIVERSION ON GUT HORMONE-RELEASE AND INTESTINAL STRUCTURE

Citation
T. Doi et al., EFFECT OF CHRONIC PANCREATIC-JUICE DIVERSION ON GUT HORMONE-RELEASE AND INTESTINAL STRUCTURE, Biomedical research, 15, 1994, pp. 425-430
Citations number
4
Categorie Soggetti
Medicine, Research & Experimental
Journal title
ISSN journal
03886107
Volume
15
Year of publication
1994
Supplement
2
Pages
425 - 430
Database
ISI
SICI code
0388-6107(1994)15:<425:EOCPDO>2.0.ZU;2-1
Abstract
The regulatory role of the presence of pancreatic juice in the intesti nal lumen on gut hormone release is still unclear, especially in dogs. This study was designed to elucidate the effect of chronic absence of pancreatic juice in the upper intestinal lumen on gut hormone release and subsequent changes of intestinal structure using chronic pancreat ic juice diversion model. Models were prepared in mongrel dogs. Isolat ed duodenal pouch containing pancreatic papilla was transferred to the middle part of the ileum without bile duct ligation. In this model, p ancreatic juice was diverted from the proximal three-fourth of the sma ll intestine with normal bile flow. Oral butter loading tests were car ried out before and after these procedures. Plasma concentration of gu t hormones (total-GLI, GIP) were measured. Morphological changes of th e small intestine were evaluated microscopically. After pancreatic jui ce diversion, (1)Butter-stimulated release of GIP were significantly l ower than the control. (2)release of total-GLI were significantly grea ter than the control. (3)the mucosal thickness along the whole small i ntestine was significantly increased. These results suggested that chr onic absence of pancreatic juice in the intestinal lumen causes growth of the intestinal mucosa and these changes may be mediated by gut-GLI .