THE RELEASE OF NEUROTENSIN BY BILE AND TRYPSIN IN MAN

The influences of (1) intraluminal bile deficiency owing to bile duct obstruction plus (2) exogenous administration of pooled own bile and b ovine trypsin into the duodenum as the effect of plasma neurotensin to oral fat (Lipomul(R)) were studied in seven patients afflicted with p eriampullary cancer as well as in ten healthy volunteers. The basal an d fat-stimulated plasma neurotensin levels in the patients were found to be significantly higher than in normal controls. Intraduodenal admi nistration of pooled own bile at the rate of 100 ml/hr considerably su ppressed the secretion of fat-stimulated enhanced neurotensin. Simulta neous administration of 100 ml/hr of pooled own bile and 600 mg/hr of bovine trypsin further suppressed the fat-stimulated neurotensin secre tion as compared with secretion under bile infusion alone. These resul ts indicate that both intraluminal bile and trypsin exert a negative f eedback on the release of neurotensin in man.