USE OF HIGH-SPEED LIQUID-CHROMATOGRAPHY (HSLC) IN THE PHARMACEUTICAL-INDUSTRY - PRACTICAL ASPECTS AND LIMITATIONS

High performance liquid chromatography (HPLC) is widely used in drug d evelopment and quality control. The main objective is to obtain depend able results in the shortest time in order to reduce the time taken to develop drugs and to ensure better quality of the final compound. Hig h speed liquid chromatography (HSLC) helps us to reach this objective. In this paper practical aspects of HSLC are discussed mainly in terms of instrument requirements and the practical needs of users. Comparis on between HPLC and HSLC separations of pharmaceutical preparations ar e given and discussed. The contribution of HSLC to decrease solvent co nsumption and consequently analysis cost and its role in reducing envi ronmental pollution, are also mentioned.