A TFA-CLEAVABLE LINKAGE FOR SOLID-PHASE SYNTHESIS OF HYDROXAMIC ACIDS

Authors
RICHTER LS DESAI MC
Citation
Ls. Richter et Mc. Desai, A TFA-CLEAVABLE LINKAGE FOR SOLID-PHASE SYNTHESIS OF HYDROXAMIC ACIDS, Tetrahedron letters, 38(3), 1997, pp. 321-322
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
3
Year of publication
1997
Pages
321 - 322
Database
ISI
SICI code
0040-4039(1997)38:3<321:ATLFSS>2.0.ZU;2-1
Abstract
A novel linkage for the solid-phase synthesis of hydroxamic acids is d escribed. The linkage is stable to all reagents commonly used in Fmoc peptide synthsis. Cleavage is: induced by treatment with trifluoroacet ic acid, providing hydroxamic acids in high purity and good yields. Co pyright (C) 1996 Elsevier Science Ltd