Dr. Williams et al., STUDIES TOWARD FUNICULOSIN - INTRAMOLECULAR CARBONYL CONDENSATIONS USING CARBOXAMIDIMIDAZOLIDE INTERMEDIATES, Tetrahedron letters, 38(3), 1997, pp. 327-330
Internal enolate condensations, utilizing carboxamidimidazoles as acti
vated wear, provide a general synthesis of the 3,5-disubstituted-4-hyd
roxy-2-pyridinone 2 as found in funiculosin. The novel all-syn-cyclito
l, C-linked to the heterocyclic system, is prepared from croconic acid
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