STEREOSELECTIVE SYNTHESES OF 1,24-DIHYDROXY SQUALENE 2,3-22,23-DIOXIDES BY DOUBLE SHARPLESS EPOXIDATION

Authors
HAUPTFLEISCH R FRANCK B
Citation
R. Hauptfleisch et B. Franck, STEREOSELECTIVE SYNTHESES OF 1,24-DIHYDROXY SQUALENE 2,3-22,23-DIOXIDES BY DOUBLE SHARPLESS EPOXIDATION, Tetrahedron letters, 38(3), 1997, pp. 383-386
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
3
Year of publication
1997
Pages
383 - 386
Database
ISI
SICI code
0040-4039(1997)38:3<383:SSO1S2>2.0.ZU;2-9
Abstract
A few step synthesis of the (all-E) squalene diol 10 from squalene 4, its double Sharpless epoxidation to the (-)-dihydroxy squalene 2,3;22, 23-dioxide 3a, its enantiomer 3b, and the formation of a tetradeutero derivative 12 is described. Copyright (C) 1996 Elsevier Science Ltd