NUCLEIC-ACID ANALOG PEPTIDE (NAAP) - SOLID-PHASE SYNTHESIS OF A DNA ANALOG PEPTIDE

Authors
FUJII M YAMAMOTO K HIDAKA J OHTSU T
Citation
M. Fujii et al., NUCLEIC-ACID ANALOG PEPTIDE (NAAP) - SOLID-PHASE SYNTHESIS OF A DNA ANALOG PEPTIDE, Tetrahedron letters, 38(3), 1997, pp. 417-420
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
3
Year of publication
1997
Pages
417 - 420
Database
ISI
SICI code
0040-4039(1997)38:3<417:NAP(-S>2.0.ZU;2-3
Abstract
Solid phase synthesis of a nucleic acid analog peptide (NAAP), as a su bstitute for antisense or triple-helix forming oligonucleotide, is des cribed. The N-protected amino acid monomer was prepared starting from 3'-azido-3'-deoxythymidine (AZT) in 20% overall yield. Condensation of the amino acid monomer was performed using Boc-chemistry on MBHA resi n to afford a decapeptide containing 10 thymine bases in 21% overall y ield. Copyright (C) 1996 Elsevier Science Ltd