A MILD AND EFFICIENT METHOD FOR THE SELECTIVE CLEAVAGE OF TERT-BUTYLDIMETHYLSILYL ETHERS TO ALCOHOLS

Authors
MAITI G ROY SC
Citation
G. Maiti et Sc. Roy, A MILD AND EFFICIENT METHOD FOR THE SELECTIVE CLEAVAGE OF TERT-BUTYLDIMETHYLSILYL ETHERS TO ALCOHOLS, Tetrahedron letters, 38(3), 1997, pp. 495-498
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
3
Year of publication
1997
Pages
495 - 498
Database
ISI
SICI code
0040-4039(1997)38:3<495:AMAEMF>2.0.ZU;2-I
Abstract
A mild and efficient method for the selective deprotection of primary allylic and homoallylic, primary benzylic and aryl tert-butyldimethyls ilyl (TBDMS) ethers has been established using a combination of H2O an d DMSO at 90 degrees C. All other primary and secondary TBDMS ethers r emained unaffected under the reaction condition. The method is very ef fective in deprotection of TBDMS ethers in the presence of other sensi tive functional groups. Copyright (C) 1996 Published by Elsevier Scien ce Ltd