GASTRIN - PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL ROLE - CLINICAL CONSEQUENCES

Citation
Hl. Waldum et al., GASTRIN - PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL ROLE - CLINICAL CONSEQUENCES, Digestive diseases, 13(1), 1995, pp. 25-38
Citations number
NO
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
ISSN journal
02572753
Volume
13
Issue
1
Year of publication
1995
Pages
25 - 38
Database
ISI
SICI code
0257-2753(1995)13:1<25:G-PAPR>2.0.ZU;2-J
Abstract
Gastrin plays a central role in the regulation of acid secretion. It i s released by meals in quantities sufficient to explain meal-stimulate d acid secretion. Gastrin stimulates acid secretion mainly by releasin g histamine from the enterochromaffin-like (ECL) cell. Whether gastrin has any functional direct effect on the parietal cell remains to be s hown. Gastrin stimulates not only the function but also the growth of the ECL cell, and longterm hypergastrinemia may lead to ECL cell carci noids. The role of the ECL cell in human gastric carcinogenesis is con troversial, but it seems wise to avoid long-term iatrogen hypergastrin emia especially in young persons. Interestingly, the oxyntic mucosal D cell, on which gastrin has a negative trophic effect, may play a role in gastric stump carcinoma, and thus hypogastrinemia may also dispose to gastric cancer.