M. Tishler et al., ANTINEURONAL ANTIBODIES IN ANTIPHOSPHOLIPID SYNDROME WITH CENTRAL-NERVOUS-SYSTEM INVOLVEMENT - THE DIFFERENCE FROM SYSTEMIC LUPUS-ERYTHEMATOSUS, Lupus, 4(2), 1995, pp. 145-147
The presence of antineuronal antibodies was compared in 43 patients wi
th primary aPLS and 57 patients with neuropsychiatric SLE. Fifty-eight
patients with Guillain-Barre syndrome and 72 normal healthy donors se
rved as control groups. Seventeen patients in the study group had aPLS
associated with CNS involvement. Antineuronal antibodies were studied
in the sera employing a novel Row cytometric assay. The frequency of
antineuronal antibodies in patients with aPLS and CNS involvement was
not significantly different from that of patients with aPLS without CN
S disease or from that found in the control groups (12%, 19% and 7%, r
espectively). However, it was significantly different from that found
in SLE patients with CNS involvement (60%) (P < 0.001). Our results pr
ovide further evidence that unlike CNS-SLE, the major mechanism of CNS
involvement in patients with primary aPLS might not be autoantibody (
antineuronal) mediated, but rather 'thrombotic' in origin, or due to y
et unknown factors.