EFFECTS OF DANAZOL ON PROLIFERATION AND VIABILITY OF 7,12-DIMETHYLBENZ(A)ANTHRACENE-INDUCED MAMMARY-TUMORS IN RATS

Authors
YOSHIMURA S SAKAMOTO S KUDO H SUZUKI S SASSA S MATSUBARA M NAGASAWA H
Citation
S. Yoshimura et al., EFFECTS OF DANAZOL ON PROLIFERATION AND VIABILITY OF 7,12-DIMETHYLBENZ(A)ANTHRACENE-INDUCED MAMMARY-TUMORS IN RATS, Anticancer research, 15(1), 1995, pp. 61-65
Citations number
27
Categorie Soggetti
Oncology
Journal title
Anticancer research → ACNP
ISSN journal
02507005
Volume
15
Issue
1
Year of publication
1995
Pages
61 - 65
Database
ISI
SICI code
0250-7005(1995)15:1<61:EODOPA>2.0.ZU;2-C
Abstract
The suppressive effects of danazol, an isoxazol derivative of a synthe tic steroid 17a-ethinyltestosterone, on cellular viability and DNA syn thesis in 7,12-dimethylbenz(a)anthracene induced mammary tumours were investigated in adult female rats by enzyme assays and immunohistochem istry with bromodeoxyuridine (BrdU). Rats treated with danazol for 30 days showed a decrease of plasma levels of luteinizing hormone and est radiol associated with a dysfunction in hypothalamo-hypophysial-gonada l axis resulting in lower activities in succinate dehydrogenase and th ymidine kinase, and a reduction of BrdU-immunoreactive cells in mammar y tumours compared with the control, i.e., decreases of viability and pyrimidine nucleotide synthesis in tumour cells in danazol-treated rat s.