H. Matsuoka et al., LOW-DOSES OF ANTICANCER DRUGS INCREASE SUSCEPTIBILITY OF TUMOR-CELLS TO LYSIS BY AUTOLOGOUS KILLER-CELLS, Anticancer research, 15(1), 1995, pp. 87-92
Pretreatment of squamous cell carcinoma (SCC) cells from foul patients
with low doses of cisplatin, carboplatin or 5-fluorouracil increased
the susceptibility to lysis by autologous killer cells in vitro. Expos
ure of two SCC cell lines to low doses of these drugs increased the ce
ll surface expression of both HLA class I and intercellular adhesion m
olecule-1 (ICAM-1). HLA class II; neural cell adhesion molecule and B7
were not expressed on the cell surface before or after such treatment
. The results suggest that these drugs increase the susceptibility of
tumor cells to autologous cell-mediated cytotoxicity, at least in part
, by enhancing the expression of HLA class I and ICAM-1.