SELECTIVITY OF THE PLASMINOGEN-ACTIVATOR INHIBITOR (PAI-1) FOR THE ISO ENZYME OF GUANIDINOBENZOATASE ON THE SURFACE OF COLONIC-CARCINOMA CELLS

Authors
STEVEN FS ANEES M BOOTH NA
Citation
Fs. Steven et al., SELECTIVITY OF THE PLASMINOGEN-ACTIVATOR INHIBITOR (PAI-1) FOR THE ISO ENZYME OF GUANIDINOBENZOATASE ON THE SURFACE OF COLONIC-CARCINOMA CELLS, Anticancer research, 15(1), 1995, pp. 205-210
Citations number
17
Categorie Soggetti
Oncology
Journal title
Anticancer research → ACNP
ISSN journal
02507005
Volume
15
Issue
1
Year of publication
1995
Pages
205 - 210
Database
ISI
SICI code
0250-7005(1995)15:1<205:SOTPI(>2.0.ZU;2-0
Abstract
The interaction of plasminogen activator-inhibitor (PAI-1) with a cell surface protease, guanidinobenzoatase (GB), has been studied in free solution and on the surface of colonic epithelial cells. It has been d emonstrated that PAI-1 recognises and inhibits the iso enzymic form of GB associated with colonic carcinoma cells but fails to bind to the i so enzymic form of GB associated with normal donor colonic epithelial cells. This interaction is mediated by a lysyl binding site on the GB: complex formation prevents GB binding to fibrin fibrils which also in volves lysyl binding sites.