SELECTION OF OVARIAN STIMULATION PROTOCOL IS RELATED TO IVF TREATMENTOUTCOME IN WOMEN 35 YEARS OF AGE AND OLDER

Purpose: The aim of this study was to assess if the woman's age influe nced IVF treatment outcome when a long GnRHa-hMG or a CC-hMG ovarian s timulation protocol was used, Two hundred women were included in the s tudy, 100 women under the age of 35 and 100 women 35 years of age and older (mean 31.8 years and 36.7 years respectively), In the younger gr oup as well as in the older group 50 women were stimulated according t o a GnRHa-hMG protocol and 50 women received a CC-hMG regimen. Results : Significant differences between stimulation protocols were found in the older group for the mean numbers of oocytes recovered (4.7 vs 3.0) , preembryos obtained (3.2 vs 2.0) and replaced (2.3 vs 1.7), as well as pregnancy (30% vs 10%) and delivery (24% vs 4%) rates per replaceme nt. Conclusion: It is concluded that women over 35 years of age seem t o have a more favorable outcome of NF treatment when using a long GnRH a-hMG protocol compared with CC-hMG, while this difference was not as obvious and lacking statistical significance under the age of 35.