AN EFFICIENT SYNTHESIS OF (+ -)-4-AMINO-3-(4-CHLOROPHENYL)-BUTYRIC ACID - (BACLOFEN)/

Authors
IBUKA T SCHOENFELDER A BILDSTEIN P MANN A
Citation
T. Ibuka et al., AN EFFICIENT SYNTHESIS OF (+ -)-4-AMINO-3-(4-CHLOROPHENYL)-BUTYRIC ACID - (BACLOFEN)/, Synthetic communications, 25(12), 1995, pp. 1777-1782
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
25
Issue
12
Year of publication
1995
Pages
1777 - 1782
Database
ISI
SICI code
0039-7911(1995)25:12<1777:AESO(->2.0.ZU;2-2
Abstract
A new preparation of baclofen is proposed. The key step involved a reg ioselective ring opening of 2-phenylaziridine with allylmagnesium brom ide. Further oxydation of the side chain give access to 4-phenyl-pyrro lidin-2-one and to baclofen.