M. Nagase et al., PH-DEPENDENT INACTIVATION AND REACTIVATION OF RECOMBINANT SHEEP ANGIOTENSINOGEN, Bioscience, biotechnology, and biochemistry, 59(4), 1995, pp. 765-766
Purified recombinant sheep angiotensinogen (rsAngn) lost 74% of the re
activity with human renin during storage at pH 8.0 and 4 degrees C. Th
e inactivated rsAngn was reactivated by incubation at acidic pHs. This
indicates that pH-dependent inactivation and reactivation occur in rs
Angn.