BACKGROUND. Clear cell acanthoma (CCA) is a usually solitary benign ep
idermal tumor. Multiple lesions are infrequently reported. OBJECTIVE.
A case of multiple eruptive CCA is reported in which a successful cryo
therapic treatment was performed. METHODS. A 59-year-old man with vari
cose veins and dry skin presented with 17 eruptive asymptomatic papulo
-nodular lesions on both legs. RESULTS. Two lesions were excised with
a histologically confirmed diagnosis of CCA. Other lesions were treate
d with liquid nitrogen. All the lesions resolved with minimal residual
scarring after three to four treatments. CONCLUSIONS. Multiple CCA is
a rare condition; fewer than 20 cases having been described. The pres
ence of associated conditions like dry skin and varicose veins are dis
cussed. Because of the tendency of persistence of the lesions, cryothe
rapic treatment may be a useful method of therapy.