EXCLUSION MAPPING OF THE BENIGN HEREDITARY CHOREA GENE FROM THE HUNTINGTONS-DISEASE LOCUS - REPORT OF A FAMILY

A Greek family is presented in which seven members suffered from benig n hereditary chorea (a rare autosomal dominant non-progressive chorea without dementia). All patients and three informative healthy relative s were submitted to DNA analysis using probes from loci linked to Hunt ington's disease. The results con firm one previous suggestion that th ese two disorders are not allelic and that they should be considered a s two distinct genetic entities.