Cancer is a leading cause of death in the United States. Despite the d
evelopment of advanced treatment for many malignancies, a large number
of patients will require evaluation and possible surgical interventio
n for lesions which have metastasized to or directly invaded the spina
l column. The recommendations for operative intervention on these pati
ents should be made following evaluations by multiple specialties, bot
h medical and surgical. An improved understanding of the pathophysiolo
gy of malignancy and the development of advanced adjunctive treatment
modalities have improved the quality and duration of life in many pati
ents. Recent studies have demonstrated the utility of early surgery wh
en combined with other treatment modalities. Surgical techniques for t
umor resection and spine stabilization have improved the outcome of pa
tients reported in multiple surgical series. A multidisciplinary appro
ach to treatment of cancer patients with spinal involvement affords th
e patient an optimal outcome.