I. Heck et al., A COMPARISON OF CAPTOPRIL AND DIGOXIN IN THE TREATMENT OF PATIENTS WITH MILD-TO-MODERATE CHRONIC CONGESTIVE-HEART-FAILURE, Clinical therapeutics, 17(2), 1995, pp. 270-279
In a double-blind study, 116 patients (mean age, 57.6 years) with mild
-to-moderate chronic congestive heart failure who were in sinus rhythm
were randomly assigned to receive 25 mg of captopril twice daily (up
to 50 mg twice daily, if needed) plus hydrochlorothiazide (HCTZ) (grou
p 1) or 0.1 mg of digoxin twice daily plus HCTZ (group 2) for 12 month
s. During a 3- to 4-week pretreatment stabilization period, group I re
ceived a mean of 37.7 mg of HCTZ daily and group 2 received 34.9 mg da
ily. After 6 weeks and 12 months of treatment, improvement was noted i
n both treatment groups on five measures of cardiac function: exercise
tolerance, left ventricular end-diastolic diameter (LVEDD), ejection
fraction, blood pressure, and heart rate. At 12 months, significantly
greater improvement was noted in group 1 than in group 2 in exercise t
olerance (from 329 seconds at baseline to 445 seconds at 12 months in
group 1 and from 353 to 427 seconds in group 2; P < 0.05); LVEDD (from
60.5 to 56.5 mm in group 1 and from 60.3 to 57.9 mm in group 2; P < 0
.05); and blood pressure (from 103.5 to 95.6 mm Hg in group 1 and from
101.9 to 97.0 mm Hg in group 2; P < 0.03). Clinical severity (New Yor
k Heart Association class) improved in both groups; 52% of the patient
s in group 1 and 41% in group 2 dropped an average of one functional c
lass (P < 0.01). The results indicate that captopril combined with a d
iuretic is an effective initial treatment for patients with mild-to-mo
derate congestive heart failure.