Our research objective was to calculate and forecast the monthly incre
ase in medical and prescription costs for Medicaid patients with acqui
red immunodeficiency syndrome (AIDS) and compare these values with cos
ts for non-AIDS patients. A retrospective analysis of AIDS patients an
d a control group of Georgia Medicaid beneficiaries was conducted betw
een January 1, 1988, and December 31, 1991. AIDS patients were defined
using the Keyes algorithm of combinations of International Classifica
tion of Diseases, 9th Revision, Clinical Modification codes. The AIDS
patient group was matched demographically to a group of non-AIDS patie
nts. Data were adjusted to account for eligibility status, and the rat
io of AIDS costs to non-AIDS costs was modeled with an econometric tim
e series procedure. A total of 1966 AIDS patients were identified from
900,000 Medicaid recipients in the study period; 58.0% were male and
59.8% were black. Age was bimodal at less than or equal to 1 year and
33 years. The best fit for the medical cost ratios produced a signific
ant regression coefficient of .37. The initial ratio of AIDS to non-AI
DS forecast was 4.25 in January 1992. The January 2000 forecast of thi
s ratio increased to 42.56, This increase equates to an additional $85
10.19 per AIDS patient-month for January 2000 in 1991 dollars. The out
patient prescription ratio for AIDS versus non-AIDS patients was not p
redictable. However, the greatest observed discrepancies were attribut
ed to the expense for antihemophilia products. Overall, the most impor
tant finding was the accelerating medical costs for treating AIDS pati
ents compared with costs for treating non-AIDS patients. These results
may, in part, reflect additional costs for treating intravenous drug
users and pediatric AIDS patients.