Kl. Nuttall et al., INDUCTIVELY-COUPLED PLASMA-MASS SPECTROMETRY FOR TRACE-ELEMENT ANALYSIS IN THE CLINICAL LABORATORY, Annals of clinical and laboratory science, 25(3), 1995, pp. 264-271
Inductively coupled plasma mass spectrometry (ICP-MS) is a relatively
new technique for trace element analysis. The basic operating principl
es of ICP-MS are described and our experience with this technique in a
clinical setting is discussed for the analysis of serum, whole blood,
and urine. Advantages to ICP-MS include the favorable detection limit
s (0.01 to 0.1 mu g/L for many elements), simple specimen preparation,
high throughput (about 40 specimens per hour), and the ability to mea
sure more than one element simultaneously. A major disadvantage is the
high capital cost of the instrumentation. Heavier elements, such as l
ead, are well-suited for ICP-MS analysis, whereas lighter elements are
prone to more interferences. Lighter elements which are not amenable
to assay by ICP-MS include chromium and iron. The ability to measure i
sotopes is a major advantage for mass spectrometry methods and has the
potential to expand the usefulness of trace element analysis.