KHAT CHEWING AND BLADDER NECK DYSFUNCTION - A RANDOMIZED CONTROLLED TRIAL OF ALPHA(1)-ADRENERGIC BLOCKADE

Objective To assess whether the effect of chewing khat leaves (Catha e dulis) on the urodynamics of healthy males is altered by the selective alpha(1)-adrenergic blocking agent indoramin in a prospective randomi zed double-blind controlled trial. Subjects and methods The urodynamic s of 11 healthy males were studied before and during a khat chewing se ssion preceded by indoramin or placebo. Results Khat chewing produced a fall in average and maximum urine now rate. This effect was inhibite d by indoramin. Conclusions The urinary side-effects of khat chewing a re probably mediated through stimulation of alpha(1)-adrenergic recept ors.