Problems.-What is the effect of migraine on health status, defined as
the patient's physical, psychological, and social functioning? And, su
ppose that the health status of migraine sufferers appears to be impai
red, to what extent is this a consequence of migraine-associated comor
bidity rather than of migraine itself) Methods.-A group of 846 migrain
eurs, selected from the general population following IHS criteria, and
ii control group were surveyed with the Medical Outcomes Study 36-ite
m Short-Form Health Survey, Nottingham Health Profile, EuroQol instrum
ent, and the COOP/WONCA charts. Questions on demographic characteristi
cs and comorbidity were included. Results.-The health status of migrai
neurs appeared to be significantly impaired in comparison to the contr
ol group. Because statistical significance is distinct from relevance,
effect size estimators were employed. Although the direction of the d
ifferences indicated consistently a worse health status of the migrain
eurs, regardless of the instrument used, the sizes of the differences
were small to medium. Self-reported comorbidity, especially depression
, was more prevalent in the migraine group. However, this offered only
a partial explanation for the impaired health status of the migraine
group. Conclusions.-Migraine has an independent moderately deteriorati
ng effect on the daily functioning of individuals.