REVERSIBLE HEPATIC-DYSFUNCTION IN ASSOCIATION WITH CYCLOPHOSPHAMIDE THERAPY

A 5.5-year-old child with nephrotic syndrome was treated with cyclopho sphamide. After 9 weeks of therapy she developed jaundice and abnormal Liver function tests, No infective aetiology was found and the abnorm al liver function tests resolved within 5 weeks of discontinuing cyclo phosphamide, Cyclophosphamide has rarely been reported to cause liver dysfunction, but not in children treated for nephrotic syndrome, and p aediatricians should therefore be aware of its potential for inducing reversible hepatic dysfunction.