BRAIN ENERGY-METABOLISM, COGNITIVE FUNCTION AND DOWN-REGULATED OXIDATIVE-PHOSPHORYLATION IN ALZHEIMER-DISEASE

Authors
RAPOPORT SI HATANPAA K BRADY DR CHANDRASEKARAN K
Citation
Si. Rapoport et al., BRAIN ENERGY-METABOLISM, COGNITIVE FUNCTION AND DOWN-REGULATED OXIDATIVE-PHOSPHORYLATION IN ALZHEIMER-DISEASE, Neurodegeneration, 5(4), 1996, pp. 473-476
Citations number
28
Categorie Soggetti
Neurosciences
Journal title
Neurodegeneration → ACNP
ISSN journal
10558330
Volume
5
Issue
4
Year of publication
1996
Pages
473 - 476
Database
ISI
SICI code
1055-8330(1996)5:4<473:BECFAD>2.0.ZU;2-5
Abstract
Reduced brain glucose utilization in early stages of Alzheimer disease , as measured with in vivo positron emission tomography, reflects pote ntially reversible down-regulation of gene expression for oxidative ph osphorylation within neuronal mitochondria. Such down-regulation may o ccur when neuronal energy demand is first reduced by synaptic dysfunct ion or loss. (C) 1996 Academic Press Limited