CELLULAR ASPECTS OF THE INFLAMMATORY RESPONSE IN ALZHEIMERS-DISEASE

Citation
Rn. Kalaria et al., CELLULAR ASPECTS OF THE INFLAMMATORY RESPONSE IN ALZHEIMERS-DISEASE, Neurodegeneration, 5(4), 1996, pp. 497-503
Citations number
45
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
10558330
Volume
5
Issue
4
Year of publication
1996
Pages
497 - 503
Database
ISI
SICI code
1055-8330(1996)5:4<497:CAOTIR>2.0.ZU;2-D
Abstract
Cerebral amyloid beta protein deposition in Alzheimer's disease is ass ociated;with a predominantly local acute phase response that kindles r elease of various inflammatory and immune system mediators. The molecu lar events are accompanied by a profound cellular response which is la rgely orchestrated by microglia. Current evidence suggests microglia a re primarily involved in phagocytic activity and may be responsible fo r inducing further neuronal damage by generating reactive oxygen speci es and proteolytic enzymes. Antiinflammatory measures that target comp lement activation as well as microglial-mediated oxidative damage woul d provide rational therapeutic strategies. (C) 1996 Academic Press Lim ited