DETERMINATION OF THE STOICHIOMETRY AND STABILITY-CONSTANTS OF THE BETA-CYCLODEXTRIN-DEXTROMETHORPHAN INCLUSION COMPLEXES BY LIQUID-CHROMATOGRAPHY AND UV SPECTROSCOPY

Authors
THUAUD N GOSSELET NM SEBILLE B VEYRON N TACHON P
Citation
N. Thuaud et al., DETERMINATION OF THE STOICHIOMETRY AND STABILITY-CONSTANTS OF THE BETA-CYCLODEXTRIN-DEXTROMETHORPHAN INCLUSION COMPLEXES BY LIQUID-CHROMATOGRAPHY AND UV SPECTROSCOPY, Journal of inclusion phenomena and molecular recognition in chemistry, 25(4), 1996, pp. 267-281
Citations number
37
Categorie Soggetti
Chemistry,Crystallography
Journal title
Journal of inclusion phenomena and molecular recognition in chemistry → ACNP
ISSN journal
09230750
Volume
25
Issue
4
Year of publication
1996
Pages
267 - 281
Database
ISI
SICI code
0923-0750(1996)25:4<267:DOTSAS>2.0.ZU;2-N
Abstract
The inclosion of dextromethorphan (DMN) by beta-cyclodextrin (beta-CD) was studied by using chromatography, UV spectroscopy and circular dic hroism methods at 25 degrees C, pH 7.4 and 4.2. It was found that the beta CD : DMN complex has 1 : 1 stoichiometry. It is more stable al pH 7.4 than at pH 4.2. with constants respectively equal to 8000 +/- 800 M(-1) and 5750 +/- 500 M(-1), as determined by chromatography. The st ability of the complex at pH 7.4 decreases as the temperature increase s. From the van't Hoff dependence the standard entropy and enthalpy ch anges were determined at this pH.