INTERFERON-GAMMA-INDUCIBLE PROTEIN-10 (IP-10), A MEMBER OF THE C-X-C CHEMOKINE FAMILY, IS AN INHIBITOR OF ANGIOGENESIS

Angiogenesis is fundamental to a variety of physiological and patholog ical processes. While a number of factors have been identified that in duce neovascularization, it is becoming increasingly apparent that end ogenous angiostatic factors may play an important role in the regulati on of angiogenesis during wound repair, chronic inflammation, and grow th of solid tumors. In this study, we demonstrate the novel finding th at IP-10, a member of the C-X-C chemokine family, is a potent inhibito r of both IL-8 and bFGF-induced angiogenic activity using in vitro and in vivo assays of angiogenesis. These findings support the contention that IP-10 may be a pivotal cytokine in the regulation of neovascular ization. (C) 1995 Academic Press, Inc.