PREDICTION OF FUNCTIONAL OUTCOME AND TISSUE LOSS IN ACUTE CORTICAL INFARCTION

Citation
Mg. Chua et al., PREDICTION OF FUNCTIONAL OUTCOME AND TISSUE LOSS IN ACUTE CORTICAL INFARCTION, Archives of neurology, 52(5), 1995, pp. 496-500
Citations number
37
Categorie Soggetti
Clinical Neurology
Journal title
ISSN journal
00039942
Volume
52
Issue
5
Year of publication
1995
Pages
496 - 500
Database
ISI
SICI code
0003-9942(1995)52:5<496:POFOAT>2.0.ZU;2-L
Abstract
Objective: To compare the acute Alien's Prognostic Score, Canadian Neu rological Score, and subacute Barthel Index as predictors of outcome f unctional status and infarct size at 3 months in patients with acute c ortical infarction. Design: A prospective study of acute stroke predic tors and outcome measurements in a cohort of sequential hospitalized p atients. Patients: Fifty-one patients with acute cortical infarction a nd without previous disability assessed 24 hours after onset with Alie n's Prognostic Score and the Canadian Neurological Score and at 7 days with the Barthel Index. Main Outcome Measures: Mortality, Barthel Ind ex, and volumetric measurement of infarct size on computed tomography 3 months after stroke. Results: There were seven deaths. The outcome B arthel Index was measured in all 44 survivors, of whom 29 had computed tomography at the time outcome was determined. In a multivariate anal ysis, functional outcome was best predicted by Alien's Prognostic Scor e, a score of less than -15 having a sensitivity of 82% and specificit y of 97% in predicting a poor outcome (Barthel Index, less than or equ al to 12 or death). Volumetric tissue loss was predicted only by Alien 's Prognostic Score (r=.62, P<.001). Conclusions: Alien's Prognostic S core is a robust predictor of both functional outcome and tissue loss in acute cortical infarction and has a potentially important role in t he analysis of the results of acute stroke intervention trials.