SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF A MACROCYCLIC BENZAMIDE

Authors
LANGLOIS M YANG D BREMONT B SHEN S
Citation
M. Langlois et al., SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF A MACROCYCLIC BENZAMIDE, Bioorganic & medicinal chemistry letters, 5(8), 1995, pp. 795-798
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
8
Year of publication
1995
Pages
795 - 798
Database
ISI
SICI code
0960-894X(1995)5:8<795:SAPAOA>2.0.ZU;2-9
Abstract
a macrocyclic benzamide was synthesized and its affinities for 5-HT3, 5-HT4 and D-2 receptors were evaluated in binding assays. It was compa red to reference benzamides possessing a piperidine ring with various orientations of the N-substituent. It was clearly demonstrated that th e orientation of the basic nitrogen atom lone pair Is an essential str uctural parameter In the recognition of 5-HT3 and 5-HT4 receptors.