NITROGEN TRANSFER IN ESCHERICHIA-COLI GLUCOSAMINE-6P SYNTHASE - INVESTIGATIONS USING SUBSTRATE AND BISUBSTRATE ANALOGS

Authors
BADETDENISOT MA LERICHE C MASSIERE F BADET B
Citation
Ma. Badetdenisot et al., NITROGEN TRANSFER IN ESCHERICHIA-COLI GLUCOSAMINE-6P SYNTHASE - INVESTIGATIONS USING SUBSTRATE AND BISUBSTRATE ANALOGS, Bioorganic & medicinal chemistry letters, 5(8), 1995, pp. 815-820
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
8
Year of publication
1995
Pages
815 - 820
Database
ISI
SICI code
0960-894X(1995)5:8<815:NTIEGS>2.0.ZU;2-3
Abstract
The compound 2-amino-2-deoxyglucitol-6P competitively inhibits E. coli glucosamine-6P synthase with respect to fructose-6P whereas glutamate gamma-semialdehyde is a competitive inhibitor with respect to glutami ne. These compounds, which exhibit good inhibitory properties (K-m/K-i = 16 and 1000 respectively), were used in the synthesis of multisubstr ate analogs.