SIMPLE COMPOUNDS, 2-ALKYL-2-AMINO-1,3-PROPANEDIOLS HAVE POTENT IMMUNOSUPPRESSIVE ACTIVITY

Authors
FUJITA T YONETA M HIROSE R SASAKI S INOUE K KIUCHI M HIRASE S ADACHI K ARITA M CHIBA K
Citation
T. Fujita et al., SIMPLE COMPOUNDS, 2-ALKYL-2-AMINO-1,3-PROPANEDIOLS HAVE POTENT IMMUNOSUPPRESSIVE ACTIVITY, Bioorganic & medicinal chemistry letters, 5(8), 1995, pp. 847-852
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
8
Year of publication
1995
Pages
847 - 852
Database
ISI
SICI code
0960-894X(1995)5:8<847:SC2HPI>2.0.ZU;2-T
Abstract
ISP-I (myriocin, thermozymocidin) was structurally simplified to give 2-amino-2-alkyl-1,3-propanediols that were also potent immunosuppressa nts. Among the series, 2-amino-2-pentadecyl-1,3-propanediol most activ ely prolonged rat skin allograft survival and was more effective than ciclosporin.