DESIGN, SYNTHESIS, AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF 2-SUBSTITUTED-2-AMINO-1,3-PROPANEDIOLS - DISCOVERY OF A NOVEL IMMUNOSUPPRESSANT,FTY720

Authors
ADACHI K KOHARA T NAKAO N ARITA M CHIBA K MISHINA T SASAKI S FUJITA T
Citation
K. Adachi et al., DESIGN, SYNTHESIS, AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF 2-SUBSTITUTED-2-AMINO-1,3-PROPANEDIOLS - DISCOVERY OF A NOVEL IMMUNOSUPPRESSANT,FTY720, Bioorganic & medicinal chemistry letters, 5(8), 1995, pp. 853-856
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
8
Year of publication
1995
Pages
853 - 856
Database
ISI
SICI code
0960-894X(1995)5:8<853:DSASO2>2.0.ZU;2-5
Abstract
FTY720 ino-2-[2-(4-octylphenyl)ethyl]-1,3-hydrochloride), a novel synt hetic immunosuppressant led by modification of ISP-I (myriocin, thermo zymocidin) displayed potent immunosuppressive activity both in vitro a nd in vivo.