Rk. Pandey et al., REGIOSELECTIVE SYNTHESES AND SOME IN-VIVO PROPERTIES OF BENZOCHLORIN ANALOGS PREPARED FROM METHYL 9-DEOXYMESOPYROPHEOPHORBIDE, Bioorganic & medicinal chemistry letters, 5(8), 1995, pp. 857-860
Starting from methyl 9-deoxymesopyropheophorbide-a 5, regioselective s
ynthesis of a series of benzochlorins was achieved. These compounds ha
ve long wavelength absorptions in the range of 710-756 nm. The in vivo
spectroscopic properties as well as the uptake and clearance characte
ristics of some of these compounds (e.g. 13) were determined by use of
in vivo reflection spectroscopy.