REGIOSELECTIVE SYNTHESES AND SOME IN-VIVO PROPERTIES OF BENZOCHLORIN ANALOGS PREPARED FROM METHYL 9-DEOXYMESOPYROPHEOPHORBIDE

Authors
PANDEY RK METTATH SN GUPTA S POTTER WR DOUGHERTY TJ SMITH KM
Citation
Rk. Pandey et al., REGIOSELECTIVE SYNTHESES AND SOME IN-VIVO PROPERTIES OF BENZOCHLORIN ANALOGS PREPARED FROM METHYL 9-DEOXYMESOPYROPHEOPHORBIDE, Bioorganic & medicinal chemistry letters, 5(8), 1995, pp. 857-860
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
8
Year of publication
1995
Pages
857 - 860
Database
ISI
SICI code
0960-894X(1995)5:8<857:RSASIP>2.0.ZU;2-Z
Abstract
Starting from methyl 9-deoxymesopyropheophorbide-a 5, regioselective s ynthesis of a series of benzochlorins was achieved. These compounds ha ve long wavelength absorptions in the range of 710-756 nm. The in vivo spectroscopic properties as well as the uptake and clearance characte ristics of some of these compounds (e.g. 13) were determined by use of in vivo reflection spectroscopy.