DESIGN AND SYNTHESIS OF HETEROCYCLIC-ANALOGS OF MYCOPHENOLIC-ACID AS POTENTIAL CHEMOTHERAPEUTIC-AGENTS

Authors
LEE JW ANDERSON WK
Citation
Jw. Lee et Wk. Anderson, DESIGN AND SYNTHESIS OF HETEROCYCLIC-ANALOGS OF MYCOPHENOLIC-ACID AS POTENTIAL CHEMOTHERAPEUTIC-AGENTS, Bioorganic & medicinal chemistry letters, 5(8), 1995, pp. 861-866
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
8
Year of publication
1995
Pages
861 - 866
Database
ISI
SICI code
0960-894X(1995)5:8<861:DASOHO>2.0.ZU;2-U
Abstract
A series of heterocyclic analogues 3-10 of mycophenolic acid were desi gned as metabolically stable congeners possibly targeted for inosine m onophosphate dehydrogenase. The synthesis, cytotoxic and anti-HIV acti vity of these compounds are described.