THE IN-VITRO EFFECTS OF 3 LYSOSOMOTROPIC DETERGENTS AGAINST 3 HUMAN TUMOR-CELL LINES

Authors
DUBOWCHIK GM GAWLAK SL FIRESTONE RA
Citation
Gm. Dubowchik et al., THE IN-VITRO EFFECTS OF 3 LYSOSOMOTROPIC DETERGENTS AGAINST 3 HUMAN TUMOR-CELL LINES, Bioorganic & medicinal chemistry letters, 5(8), 1995, pp. 893-898
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
8
Year of publication
1995
Pages
893 - 898
Database
ISI
SICI code
0960-894X(1995)5:8<893:TIEO3L>2.0.ZU;2-G
Abstract
Three lysosomotropic detergents, N-dodecylimidazole (NDI) 1, and two n ew analogues, serine dodecylamide (SDA) 2 and O-methyl serine dodecyla mide (MSD) 3, were tested against three human tumor cell lines in vitr o: HCT116, RCA and MCF-7. All three demonstrated dose-related cytotoxi city which, except for a few cases, was also dependent on incubation t ime, and visually resembled cell death by apoptosis.