INHIBITION OF TUMOR-PROMOTER-ENHANCED PI-32-INCORPORATION INTO CELLULAR PHOSPHOLIPIDS BY FLAVONOLS FROM GENUS CHRYSOSPLENIUM

Authors
ARISAWA M SHIMIZU M SATOMI Y NISHINO A NISHINO H IWASHIMA A
Citation
M. Arisawa et al., INHIBITION OF TUMOR-PROMOTER-ENHANCED PI-32-INCORPORATION INTO CELLULAR PHOSPHOLIPIDS BY FLAVONOLS FROM GENUS CHRYSOSPLENIUM, PTR. Phytotherapy research, 9(3), 1995, pp. 222-224
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
PTR. Phytotherapy research → ACNP
ISSN journal
0951418X
Volume
9
Issue
3
Year of publication
1995
Pages
222 - 224
Database
ISI
SICI code
0951-418X(1995)9:3<222:IOTPIC>2.0.ZU;2-L
Abstract
Flavonol aglycones from the genus Chrysosplenium showed potential anti tumour-promoter activity. Three flavonols, oxyayanin A and chrysosplen ols D and E, markedly inhibited the incorporation of (32)Pi into phosp holipids of confluent HeLa cells stimulated by 12-O-tetradecanoylphorb ol-13-acetate (TPA), a potent tumour promoter. The potency of the flav onols proved to be similar to those of other antitumour-promoting flav onoids.