MOLECULAR MODELING OF N-TERMINAL REGION OF HUMAN CARDIAC MYOSIN LIGHTCHAIN-2 INDUCED DURING CARDIAC-HYPERTROPHY

Studies on the expression of phosphorylatable myosin light chain 2 (ML C2) in the cardiac tissues obtained from patients with various cardiac anomalies have shown an increased expression of MLC2 in both atrial a nd ventricular biopsy tissues of patients with atrial septal defect an d ventricular septal defect. Also, in an attempt to predict the three- dimensional structure and to identify the site of phosphorylation of t he N-terminal region of this inducible human cardiac MLC2, a model has been proposed based on computer analysis. The proposed model has indi cated that this phosphorylatable N-terminal region falls in the helica l conformation and the possible site of phosphorylation could be serin e 19, which is at the centre of the helix and might be involved in the conformational changes during muscle contraction.